MEKing Retinoids Work Better

Towards Better Health at Work

Algebraic Curves That Work Better

An algebraic curve is deened as the zero set of a polynomial in two variables. Algebraic curves are practical for modeling shapes much more complicated than conics or superquadrics. The main drawback in representing shapes by algebraic curves has been the lack of repeatability in tting algebraic curves to data. A regu-larized fast linear tting method based on ridge regression and restricting th...

Better Usability and Technical Stability Could Lead to Better Work-Related Well-Being among Physicians.

Background and Objective Finnish physicians have been increasingly dissatisfied with poor usability of the electronic patient record (EPR) systems, which they have identified as an overload factor in their work. Our aim is to specify which factors in EPRs are associated with work-related well-being of physicians. Methods A web-based questionnaire was sent to Finnish physicians younger than 65 ...

Retinoids and cancer.

The synt hetic retinoids represent a new class of drugs wh ich a re highly effective in t he treatment of a broad spectrum of dermatologic d isease, including cystic acne, psori asis, and cutaneous di sorders of keratinization [1 3]. Moreover, t he use of synthetic retinoids in cancer prevent ion and therapy fo r both cutaneous and in te rna l t umors is potent ially the most signi ficant clini...

Understanding Topical Retinoids

Retinoids have been a mainstay treatment in dermatology for over fifty years . They are synthetic compounds derived from vitamin A. Studies have shown that these derivatives help clear comedonaland inflammatory lesions while controlling the bacteria implicated in most types of acne. Originally marketed as Retin A, these topical retinoids have gone through numerous transformations over the years...